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Creatine

One of the most researched supplements: effective for performance and safe for healthy people. Its direct effect on muscle growthHypertrophy (muscle growth) A muscle getting bigger, mainly through thicker muscle fibres. More in the glossary → is small, though.

// What the research shows

The International Society of Sports Nutrition position standPosition stand An official statement by a professional society summarising the evidence on a topic. More in the glossary → (Kreider et al., 2017) summarises over 200 studies: creatine raises muscle creatine stores and improves high-intensity exercise performance. Even doses up to 30 g/day over 5 years were well tolerated in healthy people, and there's no compelling evidence of kidney harm in healthy individuals. A meta-analysisMeta-analysis A study of studies: the results of many individual studies are pooled statistically. More in the glossary → using direct imaging of muscle (Burke et al., 2023) found a small additional effect on hypertrophy, slightly larger in younger adults.

// In practice

// Limitations & open questions

People with existing kidney disease should check with a doctor. Many lean-mass studies use DXADXA and BIA Two methods for measuring body composition: DXA uses X-rays, BIA a weak electrical current. More in the glossary → or BIA, which water retention can skew.

// Sources

last reviewed: 2026-11-13

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